Melanoma Pre-Cancer Atlas (HTAN)

Unpublished t-CyCIF images of melanoma and precursor fields from two patients. The specimen from patient 1 illustrates different regions of melanoma progression from relatively normal melanocytes to precursor melanocytic dysplasia to invasive melanoma. In addition, the specimen shows different regions representing immune responses to early melanoma (inflammatory regression) as well as to invasive melanoma in the form of a brisk immune infiltrative immune response (tumor infiltrating lymphocytes “TILs”). The excision specimen from patient 2 illustrates the histologic evolution of melanoma from a precursor field to melanoma in situ, and ultimately to polypoidal invasive melanoma.

Available images

Patient 1

Severely atypical lentiginous junctional dysplastic nevus with halo-like immune response.

CyCIF image
Patient 2

Melanoma in situ, invasive and polypoid melanoma

CyCIF image
Patient 2

Inflammatory regression and brisk TILs

CyCIF image
Patient 2

Melanoma in situ, invasive melanoma, precursor field and inflammatory regression

CyCIF imagee

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Funded by NIH grants P50-GM107618, U54-HL127365, U2C-CA233262, U2C-CA233280, U54-CA225088, the Ludwig Center at Harvard, and the Ludwig Cancer Research Foundation
©2020, Laboratory of Systems Pharmacology. All rights reserved.
Please cite this resource as, RRID:SCR_016267