Differentiating macrophages are regulated by PARP inhibitors and can be harnessed to overcome PARP-inhibitor resistance in BRCA-associated triple-negative breast cancer

Anita K. Mehta, Emily M. Cheney, Christina A. Hartl, Constantia Pantelidou, Madison Oliwa, Jessica A. Castrillon, Jia-Ren Lin, Katie E. Hurst, Mateus de Oliveira Taveira, Nathan T. Johnson, William M. Oldham, Marian Kalocsay, Matthew J. Berberich, Sarah A. Boswell, Aditi Kothari, Shawn Johnson, Deborah A. Dillon, Mikel Lipschitz, Scott Rodig, Sandro Santagata, Judy E. Garber, Nadine Tung, Jessica E. Thaxton, Elizabeth A. Mittendorf, Peter K. Sorger, Geoffrey I. Shapiro, Jennifer L. Guerriero

Manuscript under review

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Wildtype vs mutant

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BRCA-WT vs BRCA1-associated TNBC

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BRCA-wildtype TNBC

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BRCA-WT TNBC 1

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BRCA-WT TNBC 2

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BRCA-WT TNBC 3

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BRCA-WT TNBC 4

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BRCA-WT TNBC 5

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BRCA-WT TNBC 6

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BRCA1-associated TNBC

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BRCA1-associated TNBC 1

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BRCA1-associated TNBC 2

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BRCA1-associated TNBC 3

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BRCA1-associated TNBC 4

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BRCA1-associated TNBC 5

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BRCA1-associated TNBC 6

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BRCA1-associated TNBC 7

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BRCA1-associated TNBC 8

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BRCA1-associated TNBC 9

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BRCA1-associated TNBC 10

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